Etodolac (Lodine)

• Type of Drug: Nonsteroidal anti-inflammatory drug (NSAID).
• Prescribed for: Osteoarthritis. Can also be prescribed for rheumatoid arthritis, ankylosing spondylitis, mild to moderate pain, tendinitis, bursitis, painful shoulder, and gout.

General Information

Etodolac is one of 16 NSAIDs used to relieve pain and inflammation. We do not know exactly how NSAIDs work, but part of their action may be due to an ability to inhibit the body’s production of a hormone called prostaglandin and to inhibit the action of other body chemicals, including cyclooxygenase, lipoxygenase, leukotrienes, lysosomal enzymes, and a host of other factors. NSAIDs are generally absorbed into the bloodstream fairly quickly. Etodolac starts relieving pain in about 30 minutes, and its effects last for 4 to 12 hours. Etodolac is broken down in the liver and eliminated through the kidneys.

Etodolac (Lodine) Cautions and Warnings

People who are allergic to Etodolac (or any other NSAID) and those with a history of asthma attacks brought on by another NSAID, by Iodides, or by Aspirin should not take Etodolac.

Etodolac can cause gastrointestinal (GI) bleeding, ulcers, and stomach perforation. This can occur at any time, with or without warning, in people who take chronic Etodolac treatment. People with a history of active GI bleeding should be cautious about taking any NSAID. Minor stomach upset, distress, or gas is common during the first few days of treatment with Etodolac. People who develop bleeding or ulcers and continue treatment should be aware of the possibility of developing more serious drug toxicity.

Etodolac can affect platelets and blood clotting at high doses, and should be avoided by people with clotting problems and by those taking Warfarin.

People with heart problems who use Etodolac may experience swelling in their arms, legs, or feet.

Etodolac can cause severe toxic effects to the kidney. Report any unusual side effects to your doctor, who may need to periodically test your kidney function.

Etodolac can make you unusually sensitive to the effects of the sun (photosensitivity).

Etodolac (Lodine) Possible Side Effects

• Most common: diarrhea, nausea, vomiting, constipation, stomach gas, stomach upset or irritation, and loss of appetite.
• Less common: stomach ulcers, GI bleeding, hepatitis, gallbladder attacks, painful urination, poor kidney function, kidney inflammation, blood and protein in the urine, dizziness, fainting, nervousness, depression, hallucinations, confusion, disorientation, tingling in the hands or feet, light-headedness, itching, increased sweating, dry nose and mouth, heart palpitations, chest pain, difficulty breathing, and muscle cramps.
• Rare: severe allergic reactions, including closing of the throat, fever and chills, changes in liver function, jaundice (yellowing of the skin or eyes), and kidney failure. People who experience such effects must be promptly treated in a hospital emergency room or doctor’s office.
  NSAIDs have caused severe skin reactions; if this happens to you, see your doctor immediately.

Etodolac (Lodine) Drug Interactions

• Etodolac can increase the effects of oral anticoagulant (blood-thinning) drugs such as Warfarin. You may take this combination, but your doctor may have to reduce your anticoagulant dose.
• Taking Etodolac with Cyclosporine may increase the toxic kidney effects of both drugs. Methotrexate toxicity may be increased in people also taking Etodolac.
• Etodolac may increase blood levels of Phenytoin, leading to increased Phenytoin side effects. Blood-Lithium levels may be increased in people taking Etodolac.
• Etodolac blood levels may be affected by Cimetidine because of that drug’s effect on the liver.
• Probenecid may interfere with the elimination of Etodolac from the body, increasing the chances for Etodolac toxic reactions.
• Aspirin and other salicylates may decrease the amount of Etodolac in your blood. These medicines should never be taken at the same time.

Food Interactions

Take Etodolac with food or a magnesium/aluminum antacid if it upsets your stomach.

Usual Dose

200 to 400 mg every 6 to 8 hours. Do not take more than 1200 mg per day. People weighing 132 pounds or less should not take more than 20 mg for every 2.2 pounds of body weight. Take each dose with a full glass of water and don’t lie down for 15 to 30 minutes after you take the medicine.

Etodolac (Lodine) Overdosage

People have died from NSAID overdoses. The most common signs of overdosage are drowsiness, nausea, vomiting, diarrhea, abdominal pain, rapid breathing, rapid heartbeat, increased sweating, ringing or buzzing in the ears, confusion, disorientation, stupor, and coma. Take the victim to a hospital emergency room at once. ALWAYS bring the medicine bottle.

Special Information

Etodolac can make you drowsy and/or tired: Be careful when driving or operating hazardous equipment. Do not take any nonprescription products with Acetaminophen or Aspirin while taking this drug; also, avoid alcoholic beverages.

Contact your doctor if you develop skin rash or itching, visual disturbances, weight gain, breathing difficulty, fluid retention, hallucinations, black or tarry stools, persistent headache, or any unusual or intolerable side effects.

If you forget to take a dose of Etodolac, take it as soon as you remember. If you take several Etodolac doses a day and it is within 4 hours of your next dose, skip the one you forgot and continue with your regular schedule; If you take Etodolac once a day and it is within 8 hours of your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose.

Etodolac (Lodine) Special Populations

Pregnancy/Breast-feeding
NSAIDs may cross into the fetal blood circulation. They have not been found to cause birth defects, but may affect a developing fetal heart during the second half of pregnancy; animal studies indicate a possible effect. Women who are or who might become pregnant should not take Etodolac without their doctors’ approval; pregnant women should be particularly cautious about using this drug during the last 3 months of their pregnancy. When the drug is considered essential by your doctor, its potential benefits must be carefully weighed against its risks.
NSAIDs may pass into breast milk, but have caused no problems among breast-fed infants, except for seizures in a baby whose mother was taking Indomethacin. Other NSAIDs have caused problems in animal studies. There is a possibility that a nursing mother taking Etodolac could affect her baby’s heart or cardiovascular system. If you must take Etodolac, bottle-feed your baby.

Seniors
Older adults may be more susceptible to Etodolac side effects, especially ulcer disease.